Two sample MR report
SHTN1_Interstitial Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.1459316 | 0.2911861 | 0.7042409 |
| Weighted median | 3 | 0.0544340 | 0.0155643 | 0.0004699 |
| Inverse variance weighted | 3 | 0.0523612 | 0.0131890 | 0.0000718 |
| Simple mode | 3 | 0.0548579 | 0.0198034 | 0.1093534 |
| Weighted mode | 3 | 0.0548242 | 0.0200825 | 0.1120707 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0005300 | 1 | 0.9816323 |
| Inverse variance weighted | 0.1040033 | 2 | 0.9493273 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0580795 | 0.1805547 | 0.8018716 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001042 | 0 | TRUE | 0.33782 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
